Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA).

ABSTRACT:

Objectives

To address the hypothesis that different types of established osteoarthritis (OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosodium iodoacetate (MIA) in the rat.

Methods

Rats received a single intra-articular injection of 0.1 mg or 1 mg MIA or saline (control). Pain behaviour (hind limb weight bearing asymmetry (WB) and hindpaw withdrawal threshold (PWT) to punctate stimulation) was assessed. Cartilage and synovium were examined by macroscopic visualisation of articular surfaces and histopathology.

Results

Both doses of MIA lowered PWTs, 1 mg MIA also resulted in WB asymmetry. Bo

SUBMITTER: Nwosu LN 

PROVIDER: S-EPMC5081684 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature