Expression of ribosomopathy genes during Xenopus tropicalis embryogenesis.

ABSTRACT:

Background

Because ribosomes are ubiquitously required for protein production, it was long assumed that any inherited defect in ribosome manufacture would be embryonically lethal. However, several human congenital diseases have been found to be associated with mutations in ribosome biogenesis factors. Surprisingly, despite the global requirement for ribosomes, these "ribosomopathies" are characterized by distinct and tissue specific phenotypes. The reasons for such tissue proclivity in ribosomopathies remain mysterious but may include differential expression of ribosome biogenesis factors in distinct tissues.

Methods

Here we use in situ hybridization of labeled antisense mRNA probes and ultra high temporal resolution RNA-Seq data to examine and compare expression of 13 disea

SUBMITTER: Robson A 

PROVIDER: S-EPMC5081970 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature