Controlling Properties and Cytotoxicity of Chitosan Nanocapsules by Chemical Grafting.

ABSTRACT: The tunability of the properties of chitosan-based carriers opens new ways for the application of drugs with low water-stability or high adverse effects. In this work, the combination of a nanoemulsion with a chitosan hydrogel coating and the following poly (ethylene glycol) (PEG) grafting is proven to be a promising strategy to obtain a flexible and versatile nanocarrier with an improved stability. Thanks to chitosan amino groups, a new easy and reproducible method to obtain nanocapsule grafting with PEG has been developed in this work, allowing a very good control and tunability of the properties of nanocapsule surface. Two different PEG densities of coverage are studied and the nanocapsule systems obtained are characterized at all steps of the optimization in terms of diameter, Z potent

SUBMITTER: De Matteis L 

PROVIDER: S-EPMC5082323 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature