Exploring the intrinsic differences among breast tumor subtypes defined using immunohistochemistry markers based on the decision tree.

ABSTRACT: Exploring the intrinsic differences among breast cancer subtypes is of crucial importance for precise diagnosis and therapeutic decision-making in diseases of high heterogeneity. The subtypes defined with several layers of information are related but not consistent, especially using immunohistochemistry markers and gene expression profiling. Here, we explored the intrinsic differences among the subtypes defined by the estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 based on the decision tree. We identified 30 mRNAs and 7 miRNAs differentially expressed along the tree's branches. The final signature panel contained 30 mRNAs, whose performance was validated using two public datasets based on 3 well-known classifiers. The network and pathway analysis were

SUBMITTER: Li Y 

PROVIDER: S-EPMC5082366 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature