Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population.

ABSTRACT:

Background

Previous studies have shown that individuals with schizophrenia have a greater risk for psoriasis than a typical person. This suggests that there might be a shared genetic etiology between the 2 conditions. We aimed to characterize the potential shared genetic susceptibility between schizophrenia and psoriasis using genome-wide marker genotype data.

Methods

We obtained genetic data on individuals with psoriasis, schizophrenia and control individuals. We applied a marker-based coheritability estimation procedure, polygenic score analysis, a gene set enrichment test and a least absolute shrinkage and selection operator regression model to estimate the potential shared genetic etiology between the 2 diseases. We validated the results in independent schizophrenia and

SUBMITTER: Yin X 

PROVIDER: S-EPMC5082512 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature