Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.

ABSTRACT:

Aim

Is modulation of skeletal muscle capillary supply by altering blood flow due to a presumptive shear stress response per se, or dependent on the vasodilator mechanism?

Methods

The response to four different vasodilators, and cotreatment with blockers of NO and prostaglandin synthesis, was compared. Femoral artery blood flow was correlated with capillary-to-fibre ratio (C:F) and protein levels of putative angiogenic compounds.

Results

All vasodilators induced a similar increase in blood flow after 14 days, with a similar effect on C:F (1.62 ± 0.05, 1.60 ± 0.01, 1.57 ± 0.06, 1.57 ± 0.07, respectively, all P < 0.05 vs. control 1.20 ± 0.01). Concomitant inhibitors revealed differential effects on blood flow and angiogenesis, demonstrating that a similar response may ha

SUBMITTER: Egginton S 

PROVIDER: S-EPMC5082534 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature