Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease.

ABSTRACT:

Objective

The purpose of this study was to examine the relationship between vascular disease (and vascular risk factors), cognition and motor phenotype in Parkinson's disease (PD).

Methods

Recently diagnosed PD cases were enrolled in a multicenter prospective observational longitudinal cohort study. Montreal cognitive assessment (normal >23, mild cognitive impairment 22 to 23 or lower but without functional impairment, and dementia 21 or less with functional impairment) and Movement Disorder Society Unified PD Rating Scale part 3 (UPDRS 3) scores were analyzed in relation to a history of vascular events and risk factors.

Results

In 1759 PD cases, mean age 67.5 (standard deviation 9.3) years, mean disease duration 1.3 (standard deviation 0.9) years, 65.2% were men, 4.7

SUBMITTER: Malek N 

PROVIDER: S-EPMC5082556 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature