Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence.

ABSTRACT:

Purpose

To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical gray matter.

Methods

The 3D gradient echo PSIR images were acquired at 0.6 mm isotropic resolution on 11 multiple sclerosis (MS) patients and 9 controls subjects using a 7 Tesla (T) MRI scanner, and 2 MS patients at 3T. Cortical abnormalities were delineated on the NPI/PSIR data and later classified according to position in the cortex.

Results

The NPI helped detect cortical lesions within the cortical ribbon with increased, positive contrast compared with the PSIR. It also provided improved intrinsic delineation of the ribbon,

SUBMITTER: Mougin O 

PROVIDER: S-EPMC5082579 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature