Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied.

ABSTRACT: Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the cell's metabolism and energy consumption. In clinical practice, the regulation of clock mechanisms is relevant to biotransformation of therapeutics. Accordingly, xenobiotic metabolism and detoxification, the two processes that directly influence drug effectiveness and toxicity, are direct manifestations of the daily oscillations of the cellular and biochemical processes taking place within the gastrointestinal, hepatic/biliary, and renal/urologic systems. Consequently, the impact of circadian ti

SUBMITTER: Selfridge JM 

PROVIDER: S-EPMC5082589 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature