RNA-Seq Count Data Modelling by Grey Relational Analysis and Nonparametric Gaussian Process.

ABSTRACT: This paper introduces an approach to classification of RNA-seq read counts using grey relational analysis (GRA) and Bayesian Gaussian process (GP) models. Read counts are transformed to microarray-like data to facilitate normal-based statistical methods. GRA is designed to select differentially expressed genes by integrating outcomes of five individual feature selection methods including two-sample t-test, entropy test, Bhattacharyya distance, Wilcoxon test and receiver operating characteristic curve. GRA performs as an aggregate filter method through combining advantages of the individual methods to produce significant feature subsets that are then fed into a nonparametric GP model for classification. The proposed approach is verified by using two benchmark real datasets and the five-fold

SUBMITTER: Nguyen T 

PROVIDER: S-EPMC5082617 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature