The Relationship between Active Trachoma and Ocular Chlamydia trachomatis Infection before and after Mass Antibiotic Treatment.

ABSTRACT:

Background

Trachoma is a blinding disease, initiated in early childhood by repeated conjunctival infection with the obligate intracellular bacterium Chlamydia trachomatis. The population prevalence of the clinical signs of active trachoma; ''follicular conjunctivitis" (TF) and/or ''intense papillary inflammation" (TI), guide programmatic decisions regarding the initiation and cessation of mass drug administration (MDA). However, the persistence of TF following resolution of infection at both the individual and population level raises concerns over the suitability of this clinical sign as a marker for C. trachomatis infection.

Methodology/principle findings

We systematically reviewed the literature for population-based studies and those including randomly selected individuals

SUBMITTER: Ramadhani AM 

PROVIDER: S-EPMC5082620 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature