Dataset Information
IRBP deficiency permits precocious ocular development and myopia.
Ontology highlight
ABSTRACT:
SUBMITTER: Markand S
PROVIDER: S-EPMC5082647 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
IRBP deficiency permits precocious ocular development and myopia.
Molecular vision 20161027
<h4>Purpose</h4>Interphotoreceptor retinoid-binding protein (IRBP) is abundant in the subretinal space and binds retinoids and lipophilic molecules. The expression of IRBP begins precociously early in mouse eye development. IRBP-deficient (KO) mice show less cell death in the inner retinal layers of the retina before eyelid opening compared to wild-type C57BL/6J (WT) controls and eventually develop profound myopia. Thus, IRBP may play a role in eye development before visually-driven phenomena. W ...[more]
