Online Haemodiafiltration Improves Inflammatory State in Dialysis Patients: A Longitudinal Study.

ABSTRACT:

Background

Patients undergoing conventional hemodialysis (C-HD) present a greater immuno-inflammatory state probably related to uremia, sympathetic nervous system (SNS) activation and /or membrane bioincompatibility, which could improve with a technique-switching to online hemodiafiltration (OL-HD). The antigen-independent pathway activation of this modified immunologic state turns dendritic cells (DC) into an accurate cell model to study these patients. The aim of this study is to further evaluate the immune-inflammatory state of patients in C-HD assessed by DC maturation.

Methods

31 patients were submitted to C-HD and after 4 months switched to the OL-HD technique. Monocytes-derived DCs from HD patients were cultured in the presence of IL-4/GM-CSF. DC-maturation was evalua

SUBMITTER: Rama I 

PROVIDER: S-EPMC5082664 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature