Chiral ammonium betaine-catalyzed asymmetric Mannich-type reaction of oxindoles.

ABSTRACT: A highly diastereo- and enantioselective Mannich-type reaction of 3-aryloxindoles with N-Boc aldimines was achieved under the catalysis of axially chiral ammonium betaines. This catalytic method provides a new tool for the construction of consecutive quaternary and tertiary stereogenic carbon centers on biologically intriguing molecular frameworks with high fidelity.

SUBMITTER: Torii M 

PROVIDER: S-EPMC5082719 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature