Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease.

ABSTRACT:

Background and purpose

Abnormalities of the retinal circulation may be associated with cerebrovascular disease. We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic population-based cohort.

Methods

A total of 1185 participants (age, 68.8±6.1 years; 77% men) underwent retinal imaging and cerebral magnetic resonance imaging. Cerebral infarcts and white matter hyperintensities were identified on magnetic resonance imaging, retinopathy was graded, and retinal vessels were measured.

Results

Higher retinopathy grade (odds ratio [OR], 1.40 [95% confidence interval (95% CI), 1.16-1.70]), narrower arteriolar diameter (OR, 0.98 [95% CI, 0.97-0.99])

SUBMITTER: Hughes AD 

PROVIDER: S-EPMC5082730 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature