Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.

ABSTRACT: The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4⁺ T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells. Type I IFN-dependent, parasite-specific IL-10 production was also observed in P. falciparum malaria patients in the field following chemoprophylaxis. Parasite-induced IL-10 suppressed inflammatory cytokine production, and IL-10 levels after drug trea

SUBMITTER: Montes de Oca M 

PROVIDER: S-EPMC5082731 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature