Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation.

ABSTRACT:

Objective

In lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ adaptive immune cell networks that amplify local tissue damage. Since conventional therapy appears ineffective for severe TII, and these patients often progress to renal failure, understanding in situ mechanisms might reveal new therapeutic targets. This study was undertaken to assess whether dysregulated apoptotic regulators maintain local adaptive immunity and drive inflammation in TII.

Methods

This study utilized novel computational approaches that, when applied to multicolor confocal images, quantified apoptotic regulator protein expression in selected lymphocyte subsets. This approach was validated using laser-capture microdissection (LCM) coupled to quantitative polymerase ch

SUBMITTER: Ko K 

PROVIDER: S-EPMC5083145 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature