Parametric Response Mapping of Bronchiolitis Obliterans Syndrome Progression After Lung Transplantation.

ABSTRACT: Bronchiolitis obliterans syndrome (BOS) remains a major complication after lung transplantation. Air trapping and mosaic attenuation are typical radiological features of BOS; however, quantitative evaluation remains troublesome. We evaluated parametric response mapping (PRM, voxel-to-voxel comparison of inspiratory and expiratory computed tomography [CT] scans) in lung transplant recipients diagnosed with BOS (n = 20) and time-matched stable lung transplant recipients (n = 20). Serial PRM measurements were performed prediagnosis, at time of BOS diagnosis, and postdiagnosis (T_pre , T₀ , and T_post , respectively), or at a postoperatively matched time in stable patients. PRM results were correlated with pulmonary function and confirmed by microCT analysis of e

SUBMITTER: Verleden SE 

PROVIDER: S-EPMC5083149 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature