Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.

ABSTRACT:

Background

Synthetic human ghrelin accelerates gastric emptying, reduces gastric accommodation, and results in numerical increases in postprandial symptom scores. The ghrelin receptor agonist, relamorelin, accelerates gastric emptying in patients with diabetic gastroparesis.

Aim

To measure pharmacological effects of relamorelin on gastric accommodation, distal antral motility, and satiation in healthy volunteers.

Methods

In a placebo-controlled, double-blind, randomized study of 16 healthy volunteers, we compared effects of 30 μg subcutaneous (s.c.) relamorelin to placebo on: (i) gastric volumes measured by single photon emission computed tomography, (ii) 1-h postprandial distal antral motility index (MI) by 15-lumen perfusion gastroduodenal manometry, and (iii) satia

SUBMITTER: Nelson AD 

PROVIDER: S-EPMC5083171 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature