Sex-specific risk factors for childhood wheeze and longitudinal phenotypes of wheeze.

ABSTRACT:

Background

Although sexual dimorphism in wheeze and asthma prevalence are well documented, sex-specific risk factors for wheeze and longitudinal wheeze phenotypes have not been well elucidated.

Objective

By using a large prebirth cohort, this study aimed to identify sex-specific risk factors for wheeze from birth through midchildhood and identify distinct longitudinal wheeze phenotypes and the sex-specific risk factors associated with these phenotypes.

Methods

Mothers reported child wheeze symptoms over the past year approximately yearly on 9 occasions starting at age 1 year. We identified sex-specific predictors of wheeze, wheeze phenotypes, and sex-specific predictors of these phenotypes by using generalized estimating equations, latent class mixed models, and multi

SUBMITTER: Tse SM 

PROVIDER: S-EPMC5083247 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature