Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B₁₂ and Hcy Status with Cognitive Functions in Chinese Adults.

ABSTRACT:

Background/aim

Studies have indicated a relationship between either gene polymorphism or in vivo B vitamins' nutritional status with cognition in the elderly. However, the combined effects of MTHFR and SLC19A1gene polymorphism with serum folate and vitamin B₁₂ levels on cognition in Chinese adult population remain unclear.

Methods

Demographic information of 426 Chinese adults aged from 55 to 90 were collected by a well designed self-administered questionnaire. The Montreal Cognitive Assessment test was utilized to evaluate the cognition status of the participants. MTHFR and SLC19A1 genotyping was analyzed using polymerase chain reaction-ligase detection reaction (PCR- LDR) method. Serum folate, vitamin B₁₂ and homocysteine (Hcy) levels were detected by

SUBMITTER: Cai C 

PROVIDER: S-EPMC5084051 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature