The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.

ABSTRACT: The induction of host defense against Candida species is initiated by recognition of the fungi by pattern recognition receptors and activation of downstream pathways that produce inflammatory mediators essential for infection clearance. In this study, we present complementary evidence based on transcriptome analysis, genetics, and immunological studies in knockout mice and humans that the cytosolic RIG-I-like receptor MDA5 (IFIH1) has an important role in the host defense against C. albicans. Firstly, IFIH1 expression in macrophages is specifically induced by invasive C. albicans hyphae, and patients suffering from chronic mucocutaneous candidiasis (CMC) express lower levels of MDA5 than healthy controls. Secondly, there is a strong association between missense variants in the IFIH1 gene (

SUBMITTER: Jaeger M 

PROVIDER: S-EPMC5084092 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature