Bioinformatic curation and alignment of genotyped hepatitis B virus (HBV) sequence data from the GenBank public database.

ABSTRACT:

Background

Hepatitis B virus (HBV) DNA sequence data from thousands of samples are present in the public sequence databases. No publicly available, up-to-date, multiple sequence alignments, containing full-length and subgenomic fragments per genotype, are available. Such alignments are useful in many analysis applications, including data-mining and phylogenetic analyses.

Results

By issuing a query, all HBV sequence data from the GenBank public database was downloaded (67,893 sequences). Full-length and subgenomic sequences, which were genotyped by the submitters (30,852 sequences), were placed into a multiple sequence alignment, for each genotype (genotype A: 5868 sequences, B: 4630, C: 7820, D: 8300, E: 2043, F: 985, G: 189, H: 108, I: 23), according to the results of offli

SUBMITTER: Bell TG 

PROVIDER: S-EPMC5084120 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature