Left-right axis asymmetry determining human Cryptic gene is transcriptionally repressed by Snail.

ABSTRACT:

Background

Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-transduction and gene-expression changes identifying which remains a crucial challenge. The EGF-CFC family member Cryptic, that functions as a co-receptor for some TGF-beta ligands, is developmentally expressed in higher mammals and mutations in the gene cause loss or change in left-right axis asymmetry. Despite the strong phenotype, no transcriptional-regulator of this gene is known till date.

Results

Using promoter-analyses tools, we found strong evidence that th

SUBMITTER: Gupta K 

PROVIDER: S-EPMC5084438 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature