Growth hormone receptor expression in human gluteal versus abdominal subcutaneous adipose tissue: Association with body shape.

ABSTRACT: Growth hormone (GH) administration reduces abdominal, but not lower body, fat mass. To gain insight into the underlying mechanisms, this study examined the expression of the GH receptor (GHR) and some of its targets in abdominal and gluteal adipose tissue.GHR and GH targets in the lipolytic pathway were assessed (quantitative PCR/Western blotting) in adipose aspirates from premenopausal women [n?=?15, age 26.9?±?6.1 years, body mass index (BMI) 28.0?±?6.8 kg/m(2) ] and men (n?=?28, age 29.2?±?7.0 years, BMI 26.9?±?3.7 kg/m(2) ).GHR mRNA expression was lower in the gluteal depot when compared with the abdominal depot (P?=?0.01). Abdominal GHR correlated negatively with age and BMI, whereas gluteal GHR was associated with lower waist-to-hip ratio (WHR), that is, pear shape. In both sites, GHR mRNA correlated strongly with genes important for the regulation of lipolysis: adipose tissue triglyceride lipase (ATGL), hormone-sensitive lipase, perilipin, and CIDEA (all P?

SUBMITTER: Karastergiou K 

PROVIDER: S-EPMC5084456 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature