Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy.

ABSTRACT: Tumor cell invasion and resistance to therapy are the most intractable biological characteristics of cancer and, therefore, the most challenging for current cancer research and treatment paradigms. Refractory cancers, including pancreatic cancer and glioblastoma, show an inextricable association between the highly invasive behavior of tumor cells and their resistance to chemotherapy, radiotherapy and targeted therapies. These aggressive properties of cancer share distinct cellular pathways that are connected to each other by several molecular hubs. There is increasing evidence to show that glycogen synthase kinase (GSK)-3β is aberrantly activated in various cancer types and this has emerged as a potential therapeutic target. In many but not all cancer types, aberrant GSK3β sustains the sur

SUBMITTER: Domoto T 

PROVIDER: S-EPMC5084660 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature