Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study.

ABSTRACT:

Objective

To examine the effect of maternal exposure to asthma medications on the risk of congenital anomalies.

Design

Meta-analysis of aggregated data from three cohort studies.

Setting

Linkage between healthcare databases and EUROCAT congenital anomaly registries.

Population

519 242 pregnancies in Norway (2004-2010), Wales (2000-2010) and Funen, Denmark (2000-2010).

Methods

Exposure defined as having at least one prescription for asthma medications issued (Wales) or dispensed (Norway, Denmark) from 91 days before to 91 days after the pregnancy start date. Odds ratios (ORs) were estimated separately for each register and combined in meta-analyses.

Main outcome measures

ORs for all congenital anomalies and specific congenital anomalies.

Results

SUBMITTER: Garne E 

PROVIDER: S-EPMC5084768 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature