Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides.

ABSTRACT: The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and ethyl acetate, with no loss of selectivity.

SUBMITTER: Salomo E 

PROVIDER: S-EPMC5084810 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature