CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

ABSTRACT: Kidney dendritic cells (DCs) regulate nephritogenic T cell responses. Most kidney DCs belong to the CD11b⁺ subset and promote crescentic GN (cGN). The function of the CD103⁺ subset, which represents <5% of kidney DCs, is poorly understood. We studied the role of CD103⁺ DCs in cGN using several lines of genetically modified mice that allowed us to reduce the number of these cells. In all lines, we detected a reduction of FoxP3⁺ intrarenal regulatory T cells (T_regs), which protect against cGN. Mice lacking the transcription factor Batf3 had a more profound reduction of CD103⁺ DCs and T_regs than did the other lines used, and showed the most profound aggravation of cGN. The conditional reduction of CD103⁺ D

SUBMITTER: Evers BD 

PROVIDER: S-EPMC5084885 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature