Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain.

ABSTRACT: Purpose To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain. Materials and Methods The institutional review board approved this prospective, HIPAA-compliant, randomized, double-blinded, placebo-controlled clinical trial, and all patients provided informed consent. Twenty-six subjects (age range, 22-62 years) were enrolled. Functional magnetic resonance (MR) imaging was performed with a psychomotor vigilance task (sustained attention) and delayed match-to-sample tasks (short-term memory) before and 1 hour after administration of low-dose methylene blue or a placebo. Cerebrovascular reactivity effects were also measured with the carbon dioxide challenge, in which a 2 × 2 repeated-measures analys

SUBMITTER: Rodriguez P 

PROVIDER: S-EPMC5084971 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature