Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells.

ABSTRACT: Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based therapies may offer an alternative approach given that the eye is amenable to such treatments and corneal diseases like keratoconus have been associated specifically with the death of corneal keratocytes. The ability to generate corneal keratocytes in vitro may enable a cell-based therapy to treat patients with keratoconus. Human induced pluripotent stem cells (hiPSCs) offer an abundant supply of cells from which any cell in the body can be derived. In the present study, hiPSCs were successfully differentiated into neural crest cells (NCCs), the embryonic precursor to kerato

SUBMITTER: Naylor RW 

PROVIDER: S-EPMC5085044 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature