Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.

ABSTRACT:

Background

Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.

Methods

In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized

SUBMITTER: Sheehan WJ 

PROVIDER: S-EPMC5085065 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature