Genetic biomarkers for the risk of seizures in long QT syndrome.

ABSTRACT:

Objectives

The coprevalence, severity, and biomarkers for seizures and arrhythmias in long QT syndrome (LQTS) remain incompletely understood.

Methods

Using the Rochester-based LQTS Registry, this study included large cohorts of LQTS1-3 participants (LQTS⁺, n = 965) and those without a LQTS mutation (LQTS^-, n = 936).

Results

Compared to LQTS^- participants, there was a higher prevalence of LQTS1, LQTS2, and LQTS⁺ participants classified as having seizures (p < 0.001, i.e., history of seizures/epilepsy or antiseizure medication). LQTS⁺ participants with longer corrected QT interval (QT_c) durations were more likely to have seizures. LQTS2 mutations in the KCNH2 pore domain were positive predictors for both

SUBMITTER: Auerbach DS 

PROVIDER: S-EPMC5085072 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature