Cognitive decline following incident and preexisting diabetes mellitus in a population sample.

ABSTRACT:

Objective

To examine if incident and preexisting diabetes mellitus (DM) were associated with cognitive decline among African Americans (AAs) and European Americans (EAs).

Methods

Based on a prospective study of 7,740 older adults (mean age 72.3 years, 64% AA, 63% female), DM was ascertained by hypoglycemic medication use and Medicare claims during physician or hospital visits, and cognition by performance on a brief battery for executive functioning, episodic memory, and Mini-Mental State Examination (MMSE). Decline in composite and individual tests among those with incident DM, with preexisting DM, and without DM was studied using a linear mixed effects model with and without change point.

Results

At baseline, 737 (15%) AAs and 269 (10%) EAs had preexisting DM. Anoth

SUBMITTER: Rajan KB 

PROVIDER: S-EPMC5085078 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature