Micronized Organic Magnesium Salts Enhance Opioid Analgesia in Rats.

ABSTRACT:

Purpose

As previously reported, magnesium sulphate administered parenterally significantly increased an opioid antinociception in different kinds of pain. Since the typical form of magnesium salts are poorly and slowly absorbed from the gastrointestinal tract we examined whether their micronized form could increase opioids induced antinociception.

Methods

In behavioural studies on rats morphine, tramadol and oxycodone together with magnesium (lactate dihydrate, hydroaspartate, chloride) in micronized (particles of size D90 < 50 μm) and conventional forms were used. Changes in pain thresholds were determined using mechanical stimuli. The intestinal absorption of two forms of magnesium lactate dihydrate (at the doses of 7.5 or 15 mg ions) in the porcine gut sac model were also

SUBMITTER: Bujalska-Zadrozny M 

PROVIDER: S-EPMC5085085 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature