Rescaling of Spatio-Temporal Sensing in Eukaryotic Chemotaxis.

ABSTRACT: Eukaryotic cells respond to a chemoattractant gradient by forming intracellular gradients of signaling molecules that reflect the extracellular chemical gradient-an ability called directional sensing. Quantitative experiments have revealed two characteristic input-output relations of the system: First, in a static chemoattractant gradient, the shapes of the intracellular gradients of the signaling molecules are determined by the relative steepness, rather than the absolute concentration, of the chemoattractant gradient along the cell body. Second, upon a spatially homogeneous temporal increase in the input stimulus, the intracellular signaling molecules are transiently activated such that the response magnitudes are dependent on fold changes of the stimulus, not on absolute levels. However

SUBMITTER: Kamino K 

PROVIDER: S-EPMC5085096 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature