The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation.

ABSTRACT: Long non-coding RNAs are important regulators of gene expression and signaling pathways. The expression of long ncRNAs is dysregulated in cancer and other diseases. The identification and characterization of long ncRNAs is often challenging due to their low expression level and localization to chromatin. Here, we identify a functional long ncRNA, PARROT (Proliferation Associated RNA and Regulator Of Translation) transcribed by RNA polymerase II and expressed at a relatively high level in a number of cell lines. The PARROT long ncRNA is associated with proliferation in both transformed and normal cell lines. We characterize the long ncRNA PARROT as an upstream regulator of c-Myc affecting cellular proliferation and translation using RNA sequencing and mass spectrometry following depletion o

SUBMITTER: Vucicevic D 

PROVIDER: S-EPMC5085129 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature