Gene-based analysis identified the gene ZNF248 is associated with late-onset asthma in African Americans.

ABSTRACT:

Background

Late-onset asthma (LOA) has distinct characteristics and its pathogenesis might rely on unique pathways. Although current studies are focused primarily on childhood asthma, more research is needed to show the mechanisms underlying LOA.

Objective

To conduct genomewide association analysis and gene-based analysis to identify single-nucleotide polymorphisms and genes associated with LOA.

Methods

The Women's Health Initiative (WHI) observational cohort and the Multi-Ethnic Study of Atherosclerosis (MESA) were used to identify subjects with LOA. The association between LOA and body mass index and smoking was evaluated. In the discovery stage of the genetic analysis, 1,218 African American subjects from WHI with genotype data (271 cases and 947 controls) were use

SUBMITTER: Wang L 

PROVIDER: S-EPMC5085297 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature