APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome.

ABSTRACT: The proteasome is a multienzymatic complex that controls the half-life of the majority of intracellular proteins, including those involved in apoptosis and cell-cycle progression. Recently, proteasome inhibition has been shown to be an effective anticancer strategy, although its downregulation is often accompanied by severe undesired side effects. We previously reported that the inhibition of acylpeptide hydrolase (APEH) by the peptide SsCEI 4 can significantly affect the proteasome activity in A375 melanoma or Caco-2 adenocarcinoma cell lines, thus shedding new light on therapeutic strategies based on downstream regulation of proteasome functions. In this work, we investigated the functional correlation between APEH and proteasome in a panel of cancer cell lines, and evaluated the cell pr

SUBMITTER: Palumbo R 

PROVIDER: S-EPMC5085647 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature