A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors.

ABSTRACT: Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor. Providing effective treatment for these cancers, with minimal damage to the still-developing brain, remains one of the greatest challenges faced by clinicians. Understanding the diverse events driving tumor formation, maintenance, progression, and recurrence is necessary for identifying novel targeted therapeutics and improving survival of patients with this disease. Genomic copy number alteration data, together with clinical studies, identifies c-MYC amplification as an important risk factor associated with the most aggressive forms of medulloblastoma with marked metastatic potential. Yet despite this, very little is known regarding

SUBMITTER: Staal JA 

PROVIDER: S-EPMC5085772 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature