Enhancement of mammographic density measures in breast cancer risk prediction.

ABSTRACT:

Background

Mammographic density is a strong risk factor for breast cancer.

Methods

We present a novel approach to enhance area density measures that takes advantage of the relative density of the pectoral muscle that appears in lateral mammographic views. We hypothesized that the grey scale of film mammograms is normalized to volume breast density but not pectoral density and thus pectoral density becomes an independent marker of volumetric density.

Results

From analysis of data from a Swedish case-control study (1,286 breast cancer cases and 1,391 control subjects, ages 50-75 years), we found that the mean intensity of the pectoral muscle (MIP) was highly associated with breast cancer risk [per SD: OR = 0.82; 95% confidence interval (CI), 0.75-0.88; P = 6 × 10(-7)] a

SUBMITTER: Cheddad A 

PROVIDER: S-EPMC5085828 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature