Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery.

ABSTRACT:

Background

Cardiac maturation during perinatal transition of heart is critical for functional adaptation to hemodynamic load and nutrient environment. Perturbation in this process has major implications in congenital heart defects. Transcriptome programming during perinatal stages is an important information but incomplete in current literature, particularly, the expression profiles of the long noncoding RNAs (lncRNAs) are not fully elucidated.

Methods and results

From comprehensive analysis of transcriptomes derived from neonatal mouse heart left and right ventricles, a total of 45 167 unique transcripts were identified, including 21 916 known and 2033 novel lncRNAs. Among these lncRNAs, 196 exhibited significant dynamic regulation along maturation process. By implementing

SUBMITTER: Touma M 

PROVIDER: S-EPMC5085833 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature