Hypercalcemia in Patients with Williams-Beuren Syndrome.

ABSTRACT:

Objective

To evaluate the timing, trajectory, and implications of hypercalcemia in Williams-Beuren syndrome (WBS) through a multicenter retrospective study.

Study design

Data on plasma calcium levels from 232 subjects with WBS aged 0-67.1 years were compared with that in controls and also with available normative data. Association testing was used to identify relevant comorbidities.

Results

On average, individuals with WBS had higher plasma calcium levels than controls, but 86.7% of values were normal. Nonpediatric laboratories overreport hypercalcemia in small children. When pediatric reference intervals were applied, the occurrence of hypercalcemia dropped by 51% in infants and by 38% in toddlers. Across all ages, 6.1% of the subjects had actionable hypercalcemia. I

SUBMITTER: Sindhar S 

PROVIDER: S-EPMC5085847 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature