Selective Internal Radiation Therapy With Yttrium-90 Glass Microspheres: Biases and Uncertainties in Absorbed Dose Calculations Between Clinical Dosimetry Models.

ABSTRACT:

Purpose

To quantify differences that exist between dosimetry models used for ⁹⁰Y selective internal radiation therapy (SIRT).

Methods and materials

Retrospectively, 37 tumors were delineated on 19 post-therapy quantitative ⁹⁰Y single photon emission computed tomography/computed tomography scans. Using matched volumes of interest (VOIs), absorbed doses were reported using 3 dosimetry models: glass microsphere package insert standard model (SM), partition model (PM), and Monte Carlo (MC). Univariate linear regressions were performed to predict mean MC from SM and PM. Analysis was performed for 2 subsets: cases with a single tumor delineated (best case for PM), and cases with multiple tumors delineated (typical clinical scenario). Variability in PM from th

SUBMITTER: Mikell JK 

PROVIDER: S-EPMC5085875 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature