Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae: an observational study.

ABSTRACT:

Background

New approaches are urgently required to address increasing rates of gonorrhoea and the emergence and global spread of antibiotic-resistant Neisseria gonorrhoeae. We used whole-genome sequencing to study transmission and track resistance in N gonorrhoeae isolates.

Methods

We did whole-genome sequencing of isolates obtained from samples collected from patients attending sexual health services in Brighton, UK, between Jan 1, 2011, and March 9, 2015. We also included isolates from other UK locations, historical isolates from Brighton, and previous data from a US study. Samples from symptomatic patients and asymptomatic sexual health screening underwent nucleic acid amplification testing; positive samples and all samples from symptomatic patients were cultured for N go

SUBMITTER: De Silva D 

PROVIDER: S-EPMC5086424 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature