Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model.

ABSTRACT: Post-traumatic osteoarthritis affects almost 20% of the adult US population. An injurious impact applies a significant amount of physical stress on articular cartilage and can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis. In our effort to understand the underlying biochemical mechanisms of this debilitating disease, we have constructed a multiscale mathematical model of the process with three components: cellular, chemical, and mechanical. The cellular component describes the different chondrocyte states according to the chemicals these cells release. The chemical component models the change in concentrations of those chemicals. The mechanical component contains a simulation of a blunt impact applied onto a cartilage explant and the resulti

SUBMITTER: Kapitanov GI 

PROVIDER: S-EPMC5086581 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature