The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration.

ABSTRACT: The purpose of this study was to evaluate the association of the hepatic lipase (LIPC) rs493258 polymorphism and susceptibility to age-related macular degeneration (AMD). A systematic search in PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to April 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) in different stages of AMD were estimated under different genetic models using meta-analytic methods. Seven studies comprising 20,559 cases and 17,200 controls met the inclusion criteria and were included in the meta-analysis. The LIPC rs493258 polymorphism showed a significant association with a lower risk of AMD under the allelic model (OR = 0.87, 95% CI = 0.84-0.90). Significant relationsh

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5086761 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature