Antagonistic autoregulation speeds up a homogeneous response in Escherichia coli.

ABSTRACT: By integrating positive and negative feedback loops, biological systems establish intricate gene expression patterns linked to multistability, pulsing, and oscillations. This depends on the specific characteristics of each interlinked feedback, and thus one would expect additional expression programs to be found. Here, we investigate one such program associated with an antagonistic positive and negative transcriptional autoregulatory motif derived from the multiple antibiotic resistance (mar) system of Escherichia coli. We studied the dynamics of the system by combining a predictive mathematical model with high-resolution experimental measures of the response both at the population and single-cell level. We show that in this motif the weak positive autoregulation does not slow down but rat

SUBMITTER: Rodrigo G 

PROVIDER: S-EPMC5086920 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature