Human mitochondrial ribosomes can switch their structural RNA composition.

ABSTRACT: The recent developments in cryo-EM have revolutionized our access to previously refractory structures. In particular, such studies of mammalian mitoribosomes have confirmed the absence of any 5S rRNA species and revealed the unexpected presence of a mitochondrially encoded tRNA (mt-tRNA) that usurps this position. Although the cryo-EM structures resolved the conundrum of whether mammalian mitoribosomes contain a 5S rRNA, they introduced a new dilemma: Why do human and porcine mitoribosomes integrate contrasting mt-tRNAs? Human mitoribosomes have been shown to integrate mt-tRNA^Val compared with the porcine use of mt-tRNA^Phe We have explored this observation further. Our studies examine whether a range of mt-tRNAs are used by different mammals, or whether the mt-tRNA se

SUBMITTER: Rorbach J 

PROVIDER: S-EPMC5087001 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature