State dependent cortico-amygdala circuit dysfunction in bipolar disorder.

ABSTRACT:

Background

Existing models of the pathophysiology of bipolar disorder posit disruption in neural circuits of emotion regulation and reward processing. However, few fMRI studies have compared regional brain activity and connectivity in different mood states in bipolar disorder to determine if manic symptomatology is reflected in specific circuit abnormalities. The purpose of this study was to test the hypothesis that bipolar mania is associated with altered connectivity between cortical regions thought to regulate subcortical structures such as the amygdala and striatum.

Methods

28 subjects with bipolar disorder in a manic state, 24 different bipolar subjects in a euthymic state, and 23 matched healthy comparison subjects underwent resting state fMRI scans. Several cortical a

SUBMITTER: Brady RO 

PROVIDER: S-EPMC5087105 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature